Big carb (Quick Fuel 850) on a small engine?

1MeanA said

Big carbs will have lower vacuum in the venturi meaning weaker pull on the fuel. This results in poor responsiveness and difficulty in tuning.

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So wouldn't the question be what's the ideal vacuum compromise for different applications eg.. Race only, street strip, street machine, daily driver etc.. Seems like almost no one run's 1.5" hg.