I was running spacers at first, with the 13" DoctorDiff style cobra brakes I'm not running spacers anymore. I have 275/35/18's up front with 18x9's that are +35 offset. My wheels do touch the frame at full lock, but that's because my QA1 tubular LCA's don't have a steering stop. Not likely to be an issue with factory LCA's.
Initially I got away with not having the fenders rolled, but at my current ride height my fenders needed to be rolled and pushed so as not to cause rubs when compressing the suspension with the wheels turned sharply. You could probably get away with not having as much clearance as I've done, but I try to set mine up so I can drive "normally" and not creep over every bump and dip.