This carb or a Holley 2300?

The weber could be the better carb. But the 4412 isnt really 500 cfm. Its identical in size to the front half of a 750dp (1.375 venturi, 1.687 throttle bore), so, 375? The correction factor to rate a two barrel the same way as the four barrels we are familiar with is to divide by square root of 2, that comes out to 354 cfm.
You need to remember, a 2 barrel sizes differently, because it measures at 1.5 hg and not 3 hg like a 4 barrel. If it was really a 375, what would be the point of making a 350?