MS3 , Multiport & turbo build

I read through the documentation of the MS3Pro last night to try and get an idea for how it works. It looks like you can adapt a points distributor to function as a camshaft sensor using a Hall effect sensor. OP's setup for the crank is the only setup I can think of to get an accurate reading of crank timing on a /6.
I see little benefit to the Ford EDIS system from what I was reading, since LS parts, especially coil packs, are readily available and the MS3Pro can easily control them for sequential ignition.
As far as setups go, this makes sense to me. I've been looking at switching to EFI for a while, and the Sniper/FiTech systems just don't seem worth it, they're glorified carbs, whereas a proper ECU controlling injection and ignition can adjust spark and injection timing to get better, more efficient performance across the entire RPM range.

I'm definitely interested to see how the OP does coil-on-plug mounting for this.
I agree that a TBI (FiTech, ...) would give only minor benefit on a straight-six. It is basically a "better carburetor", having less goofy cold fuel enrichment (rather than a choke) and perhaps better management of transients (replace accel pump) and enrichment at max power ("economizer" in Holley 1920), and finer droplet spray. But, it doesn't address perhaps the biggest problem with single-point injection, which is equally distributing the fuel among the cylinders, other than finer droplets helps (forcibly sprayed rather than suck-atomized). Multi-point injection (MPFI) does that, assuming the injectors are flow-matched.

My thoughts for using an EDIS processor are for use with a Holley Commander 950 controller which can command spark timing. That output is designed for the GM 8-pin HEI module (1985-95 small-cap distributor), and is via reflecting back a sawtooth wave sent by the module ("SAW"), with a delay. Similar is done to command timing in the EDIS module. I recall, the delays have different meaning in degrees between the two, but been a while since I thought about it. Have all the parts, but has never risen to the top of my list. Correct that with a megasquirt processor works directly from the 36-1 trigger wheel signal, counting the teeth directly in software. The EDIS likely uses custom digital logic to process the 36-1 signal, or at least a mini-processor with embedded code you can't access (perhaps burned into memory like an ASIC chip).