Since Hughes seems to specialize in Mopar parts, their cam grinds maybe based on Mopar profiles that take advantage of the large .903 diameter lifter that Mopars use. I know a lot of slant six folks like to use Oregon Cam Grinders, and I have also, but most of their cam profiles are based on Comp Cam and other Chevy profiles that are made to accommodate the small diameter Chevy lifter. The smaller diameter lifter requires a slower opening ramp. A larger diameter lifter can accommodate a faster opening ramp.
The last cam that I ordered from Oregon they had to look long to find a grind that was made for the larger lifter. If I was to order another slant six cam I would be talking to the folks at Hughes to see if their lobes are made from Mopar masters and designed for the larger Mopar lifter.
Concerning the cam choice that you have listed.
You did not mention the target compression ratio that you are building to. That is one of the considerations.
With a target of 8.5 to 9.0 that Hughes cam would be fine.
Most slant six folks would advance that cam a bit to get to a 102 or 101 ICL.
I would put that all through an online dynamic compression calculator to see what that number is.
For the timing chain. If you degree the cam, you take the possibility of error in the timing chain marking out of the equation. You can also get the ICL where you want it.
Buy a Cloyes or equivalent, a degree wheel and degree the cam and get the cam set right.