Big Inch Smallblock
My stoker is at 421ci with a 4.125" crank. I got the forged crank/rods from Ohio Crankshaft. Pistons are from Ross. Chevy journals.
The block was a 91' LA roller. We did not have to clearance the block. With a 4.250" it's possible you may have to touch it. Just make sure whatever oil pan you get will accommodate the stroke. I also learned through dyno testing that the extra cube will eat the cam. I went way too small with my initial cam duration. I'm in the process of swapping that cam for a larger one now.
I did a thread about it if you search my profile