Can cam support gear change?

70 Dart 340 rebuilt, compression coming in right at 9.8:1. With the lunati 703 cam. Tire height is 25.7" (245/45/17) Currently have 4.10 gears with Hemi OD 4 speed gears. Ratios are:

1st: 2.66
2nd: 1.59
3rd: 1:0
4th: .80

I'd like to have more drivability on the hwy. Was thinking about 3.23, but not sure if my cam will like that high of gear.

Thoughts?

You need an online calculator to figure out the rest.
You need to be honest with your cruising speed.

3.23 X .80 = 2.56 final drive ratio.

With that math done, add in tire size and speed you want to travel at on the calculator. This will give you the RPM. For automatic transmission guys, converter slip not included but it maybe an option on the calculator. The known slip percentage of your converter is what?