Crazy Fixes:
2000 E150 Van misfire on #4 (5.4) and I was out on the interstate with a long ways to go.
Had replaced coil and spark plug on #4 a month earlier. Then out on the freeway it stated acting up again.
They say moisture or anti-freeze/steam gets in around the coil boot and grounds out the spark plug lead.
Pulled the doghouse at a gas stop, had a fresh can of WD-40 with me so I sprayed down #4 coil and boot and clip electrical connector.
Fired it up and it was back to 100% again, the WD-40 displaced any moisture and stopped the misfire immediately.
On the freeway again thinking: Back to Full Power.
Oh Yeah!
By all means worth a try.
☆☆☆☆☆