Hughes STL5460AS-8 vs Lunati 40200913LUN cam

IMHO when you ask a question like this you need to provide more information regarding intended end use, engine displacement and the intended vehicle.
These days I would look hard at the roller, considering oils availability. Lifter durability can go either way. Staying away from cut rate Chinesium components ups the durability factor immensely.
For my 289, I have a flat tappet mild cam taken out of my 351. Because I have this good condition cam I will use it. If I had to purchase a cam I would go for a roller cam and Morel lifters. That will explode the wallet, but you do not want a failure of cheap parts causing a failure requiring a complete teardown.
^^^^^^^^^^^^^^^^^^^^

Because doing it twice is more expensive than doing it right once.