Is it possible for 318 to run with dist. 180 deg. off ???

The engine runs rough no matter, timing mark off 90* .
Something's whacked besides me.
Check your firing order, #2 is right beside #1, which is 90* on the crank .
Try timing it off #6, if the mark is in the right place, #1 and #2 wires may be crossed.
Did you own a Ford prior to this ? .lol