EFI
I posted on your moparts thread also. My setup has been extremely consistent. Its is a Megasquirt system that I do all the tuning on.
The "self learning" stuff is only as good as the info you give it. Everything really needs a good base tune to hit the AFR targets you choose for your combo. For example my car runs the best at 13.0:1 AFR. That is my target and after enough time the tune is close enough to the target that it can easily make small corrections to hit the ratio even as weather changes. That being said 13.0:1 AFR in 500ft DA goes way faster than 13.0 AFR in 4000ft DA.
I just did Drag Week and we raced at tracks 130ft above sea level and a track at almost 3000ft above. My car hit the target AFR on every pass and I made zero changes to the wide open tune. The ET varied with the DA as expected with any combo. The only changes I made all week were drivability stuff like overrun fuel cut and part throttle AFR targets.