Slant 6 4bbl Carb Selection
You don't have to worry about the secondaries on the 750 Edelbrock. They will never open because there would not be enough air flow in a sorta stock engine. The primaries are no bigger the then a 350 Holley or for that matter an Autolite 21xx which are good carburetors. So it should work.
Dutra ran a 750 Edelbrock on his 210" green toad car. This was a 12 second car on nitrous. It also had a corresponding fuel system capable of fueling the system. This included a Dutra HyperPac, a set of his cast iron exhaust manifolds and 110 gph mechanical fuel pump.