There’s several problems to your build.
To much converter, unknown gear size and tire, unknown compression, unknown heads and valve sizes but since it’s a 360 and we have to assume stock, we are looking at a 72 cc chamber with 1/88/1.60 valves on a head that flows 200cfm.
Further complications are your worry of vacuum. The 110 is normally a boarder line cam with a few factors keeping it there. So much depends on the love and overlap amount.
The 108 LSA cam I have and the single pattern duration isn’t and should never be a deal breaker as the split duration cam is more focused on extra top end power as it’s asset. At 3700lbs, I would t be worried.
Remember, Howard’s (and any other cam grinder) will adjust the LSA and move ether or both lobes to make it happen for you. If you like the split duration cam more for its duration and lift, you can ask Howard’s to adjust it or ask them which route would be better in the less than ideal combo you have there.
Comp Cams did it for me on my XL285HL with a nominal charge.
All of this is figured you know by now.