1965 MOPAR, 273 Exhaust Maifolds

The ports will match up just fine, however-
If the heads are '73 ish or earlier, and have this shape pad around the ports, you will be fine.
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But if you've got '74/'75 ish or later heads with the extended pads (made for air injection, may be drilled or may not, needs to be plugged if it is), like this:
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Then there will be interference between the bottom portion of the exhaust pad on #7 and the downleg of the exhaust manifold, which will not allow you to tighten down the manifold to the head.
The amount of interference varies due to manufacturing tolerances, sometimes you can get away by double gasketing the manifold, sometimes you have to use a spacer, normally a header flange, to gain the needed clearance.
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Some say that they have been able to grind enough of the offending pad to get it to fit, but I have personally hit the water jacket just under the surface with minimal grinding- up to you if you want to take that chance and trash a head. Even if you don't hit the jacket, how thin is the metal that's left? I play it safe now and just use the spacer.
But as I previously said, if you have the earlier heads, it's no problem.
Edit: Just to clarify, to my knowledge this is only an issue with the (early) A body manifold, and only on the driver's side.