Probably a real dumb question but ....
I have been plannjng to add a belt blower or turbo to my red 66 charger. It is 11.5ish to 1 and even with a fat cometic gasket I'd be in the danger zone on race gas.
I was told to stay under 10.5, preferably 9.5:1 under 15 lbs of boost. My understanding through research is that high compresion and/or anything beyond ~1 bar creates a very narrow tuning window on gasoline. The two big boost guys I know run methonal.