Probably a real dumb question but ....
Do as I say and not as I do, I know but I have my reasons.
This is my 9.2:1 489 twin turbo big block Chevy. Runs on pump gas 91 octane, non intercooled, blow through carb, in my boat. It makes around 800 at 7psi and idles like a stock big block. If I could get e85 at the dock I’d run that. If I could fit an intercooler I’d run one. But sometimes you make compromises and those compromises will limit output. We hit my power goal pretty easily and didn’t see any reason over complicate it. Start with a goal in mind (hp) and pick a fuel to run, then set the compression to the fuel. Then turn the boost up till it makes the power you want.