compression or flow?

Thinking of a cheap build with avaiable parts that i already have.
360LA block with H116CP speed pro .030 over pistons, .005 in the hole.
Set of Edelbrock untouced (used, not ported) RPM 63 cc heads Quench closed chamber)
.036 head gasket... comes up as 10.6 static compressio.
4 speed in a dart. \
I know i need to be careful picking camshaft, but will 10.6 be too much compression for pump gas?
Hot street motor.. headers, 355 gear ..maybe fuel injection...

I have never ran aluminum heads.....
I have some W-2 iron heads (70 cc and no quench, Open chamber, ported .5 point dtop in compression)and all it take to run them except pushrods.

So the question is do i give up the poeted W2 flow for higher compression and quench?
what difference will either make?