Making power out of the 318

So currently I have a slant six so i will be getting a new trans i have a 8 1/4 with 3.21s and i will be getting a new converter with the correct stall for the cam that I get
With a fairly lumpy cam and single plane lowest gear I'd go with is 3.91 on 26/27 inch tire, preferably in the 4.xx's.