The further you move away from stock mainly duration and lsa wise the more of an issue it becomes picking the right cam and designing the overall drivetrain combo, especially if you stay with stock gears stall cr etc.. , but depending on the person cause a lot of it comes personal preferences and compromises, you can generally can go up 10-15 degrees over a stock non performance cam and tighten the lsa a few degrees before more stall becomes a must and deeper gears are needed. Some might like less and some may even find bigger acceptable.