Builders: Square engine, Over Square, or Under Square for you?

How much effect does the almost 1.3 sq/in in area of the piston come into play wrt a 4 vs 4.2" bore? it's almost 10% more surface to push down so I'd have to think that has some impact. if so, how much?
I guess that might be affected more by how much compression the bigger bore has. A bigger bore will draw more mixture if everything else matches and more compression will make the piston size more effective, I assume a bigger piston also has better heat dissipation since there's more aluminum for heat to absorb.