Ailing engine (Updated after teardown)

This post actually got my head out of my arse and remember that with boost he may want to look into a boost referenced fuel pressure regulator.

That way as boost goes up it will add fuel pressure to help keep the fuel curve correct.

So a timing curve, boost retard on the ignition and a boost referenced regulator would make his tune up window much bigger.
I am running a FiTech EFI dual 4 setup and control the fuel with it. At idle my afr is 14 to 1. At cruise not under boost I go to 13 to 1. When under boost it is 11 to 1. This is a pretty rich setup that helps to cool everything down. I also run my temps at 156 degrees. The only time it goes higher is in hot weather in city type traffic and then it might push 180 degrees.

Jack