Serious vibs

Ok my gts 340 auto 727 with 373 rear I think. Problem is at 80 mph it starts to feel bad vibration and cannot drive through it. Drive shaft? Rear end? Any ideas? T I A.
Does it do it when in neutral and you rev the engine to the same rpm as when you have the problem at 80 mph? If it does then it can be ignition and carb related.