Mild 383 build
The largest advantage of a large bore and short stroke engine is that the piston ring to cylinder wall interface is responsible for the most friction loss in the engine. The less they travel along the cylinder, the presumed less friction loss. But unless you’re planning to maximize that effect with careful ring selection (I.E. thin and reduced tension), you won’t see a difference. Reher Morrison Racing did quite a bit of research into that field. Probably the biggest advantage of a larger bore engine is giving the valves a little extra breathing room. But I mostly view bore to stroke ratio with about the same regard as rod to stroke ratio. Unless you’re building for the last three or four horsepower like for nascar or other pro racing teams, there are a lot better areas to focus on for a street engine. More cubic inches is always good providing there’s adequate cylinder head to take advantage of it.