(2)450 DP's vs (2)750 DP's

Our own drag car has had various cams ranging from 269 to 289 intake duration in it, the longer the intake duration the smaller the carbys had to be to get max power out of it. And with all the different cams its always made exactly the same power because we never changed the head flows. BUT i had to make the carbys smaller to get the power back with each successively larger cam. Every time we went larger in the cam it lost power on the old carby size"
IF in the end of the day each combo made the same power, what's the value of over camming and have to run a smaller carb ? Which sounds like it was a Band-Aid solution, and smaller by how much of a difference 50/100/200 or more cfm's ?