Manifold Vacuum Advance what am I not getting?

This is the EXACT scenario I always bring up. Nowhere near enough compression and a monster cam.
I recently went through this, 20* advance in a 400, wanted more. Less than 10 inches of vacuum. Sounded wicked, ran terrible. Wouldn't fall out of a tree if you pushed it. I didn't know what exactly was wrong (cam/compression mismatch or slap worn out) but it was all used so I just pulled it out and started over.