It's R600a (isobutane) and R290a (isopropane), number one. Number two, fridges are not motor vehicles. The operating conditions are hugely different, and so are the safety factors and risks. There are plenty of refrigerants approved for use in certain applications and not in others, for that exact reason.
…in well-ventilated spaces much bigger than the passenger compartment of a car. This is a fine example of what "the operating conditions are hugely different, and so are the safety factors and risks" means.