273/ 2 barrel camshaft options

Hello and thank you for the response. I appreciate the knowledge and sorry to hear about your experience. That’s exactly why I am here, I don’t know what I don’t know, it seems that any aftermarket cam may greatly affect or upset the cam related components I’m working with. Until I hear from the machine shop I’m hopeful for a refrains and resurface with what I have, if not I’m reading more on weather the isky option would “over cam” the existing setup. Thanks again for sharing!
The Isky E4 is fine for the lower compression 2 barrel. Here's the 273 cam specs and the E 4 specs. A little extra duration and lift won't hurt a thing. There have been dozens of members here that have installed a E4 with a 2 barrel. The small carb will just limit your upper rpm.
Basic 273 cam specs:

1965 180 hp 2 barrel .395 /.405 lift 240°/ 240° duration
1965 235 hp 4 barrel .415 /.425 lift 248°/ 248° duration
1966 235 hp 4 barrel .420 /.430 lift 248°/ 248° duration
Isky E4 .425/.425 lift 260°/260° duration 216° @ .050

Here's a link to my 273 build just below.