(2)450 DP's vs (2)750 DP's

I wouldn’t worry too much about the tilt. While you’re driving the fuel in the bowls is far from static in level and always moving around. When you’re on the gas hard (when all of this tuning really matters) all of the fuel will be crammed one way in the primary and one way in the secondary. Make sure the jets are always in liquid and forget about it. Don’t overthink it.