~450hp from stock stroke 340?

That requires at least 1.32 HP per cubic inch, and while achieving that is possible, it's not going to have street manners. I suppose it's all relative to what you call street manners.

Build a 416" and you only need to make 1.08 HP per cubic inch.

Totally agree.
And that’s coming from someone who had a 450hp 340 in my car.

When you’re looking for power and civility…….cubes are your friend.

If one is determined to keep the stock stroke, my suggestion would be to more or less ignore the hp goal, and just build the engine using a selection of parts that make sense for how the vehicle will be used……. And then the hp will just be what it is.
Might be 450hp…….. might not.