15x7 4.25 backspacing on the front. Does it work?

Yep, 15x7 with a 4.25” backspace should work. This is with 225/60/15’s on my Duster

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Now, that is BBP not SBP. But even with the difference in track it should be ok. It will work with the fenders for sure, it may be pretty close to the suspension.