I'm running the MS3X on a 5.7 right now. I had it previously running my 408 LA. Since I made the harness and bulkhead connector for the 408, I simply made the harness and pinout to match. A simple config change and it fired right up. I will admit the MS was a big learning curve for me since I hadn't messed with any EFI at that point. I've considered moving over to the Terminator X, but honestly, there's no point. I feel like the Terminator is a good setup for guys that aren't familiar with EFI and don't need a bunch of extra I/O. In order to match the I/O of the MS3X on a Holley system, you would need to go with the Dominator or get a CAN expansion module. If money is no concern, go with the Dominator. Overall, I'm happy with the MS3X, but I want even more analog inputs and have considered getting a microsquirt to use as a CAN I/O extender.