Question 65 Cuda
short answer is yes.
the longer answer is, quite well and you'll need to reuse several of your 273 parts: oil pan, motor mounts, exhaust manifolds.
the water pump intake is on the passenger side instead of the driver's side. so you'll either need to get creative with the plumbing or swap over your 273 timing cover and waterpump. or swap out your radiator.
67 and earlier small block transmissions use a small torque converter hub that matches the early crankshaft register. with a later motor you'll need an adapter ring to take up that space unless you swap out your trans for something later or upgrade your torque converter ($$$).