I wouldn't switch the leads at the same time you are reworking the curve unless you know its backwords.
Yes, switch to manifold source if the current setup is causing the coolant temps to rise and not stabilize at idle. Not toalking about the usually rise that accompanies the reduction in airflow when coming to a stop.
I agree.
Fuel mixtures and timing work together. Can only do so much with the fuel mix if the timing isn't where it ought to be.
Well there's part of your answer! And unlike your car, 70 mph probbaly hurts milage vs. 60 mph.
Also any time spent idling, tuning, etc is a gas milage killer. The mpg of both my vehicles plummets when driving in the city. Literally more time spent idling than moving.
All these things add up.