i literally just finished up a 318 build: 73 block, 68 heads w/ 340 sprAngs, thin fel pro head gaskets, 340 cam advanced, LD4B, carterbrock 625, OE electronic ignition, thru manifolds. idles smooth with a little hint of lope and absolutely rips when you jam on the gas. 65 dart w/ 391's 2nd gear is all hands on deck.
so it will work. it's just that if you're buying a new cam there's better options available at basically the same price point.