Camshafts: What effect does increased lift have on performance?

Now cam numbers make my head spin, so nothing but confuse me, especially when you dig deeper like overlap,

Another question does lift or duration play more of a part in how much vacuum a given engine makes
Valve timing events.

That nano second, is the difference between an advertised 252/.425 & a 208/.600.

The difference between a OEM .410 lift and a 252/.425 can be 5-20 hp, all things being equal, good question. The variables are to many. Interesting question. I know with rebuilt engines it has been done and tested. Steve Dulchich did this before.