Camshafts and Compression

210-220 is not too much for pump fuel. I have a turbo Honda v6 in my falcon and it pumps 225, run boost, and it does it on California 91 octane. You need to put a better curve in your distributor. All in by 2700 is too early and you should delay the curve a bit around peak torque and add it in as the engine rpms. That’s not to say that you might be able to cut a camshaft more suited to your build, but you should be able to tune around the detonation with a proper curve that allows you to make the same power.
Could that have to do with having a smaller cylinder volume though? Lots of motorcycles crank over 200psi with no issues, but with only 250-300cc per cylinder. We have 840cc per cylinder here at 220!

Good call on delaying the ignition timing, it’s probably too quick.