End PLay adjustment?

When setting the endplay on the axle of an 8 3/4, is it possible to set it so loose that it would sound like the wheel hub is rubbing the axle? I can turn my wheel by hand and you can hear something rubbing in the wheel , when I take the wheel and hub off and turn the axle it( the rubbing noise) is not there. When the wheel is on and it rubs, I can pull hard on the tire and the rubbing sound stops making me believe the end play is incorrect. Any thoughts?

Mike