I think the issues are apples to oranges... By limiting heads to one brand and style, and camshaft, and compression.. and you eliminate maximizing each combo with the available parts for them. The stroke is the key in both cases.
#1....The LA RPMs will feed the 4" crank engine to 6500 with a std CNC program netting 270-280cfm. The suggested cam is smaller in terms or duration at .050 than I'd use. A solid roller would be more like 265-270°@.050 at .600 lift, and with taking out for lash and the nasty pushrod angles, that lift at the valve is closer to .560. Also, carb is on the smallish side. I think performance wise 520-540 at 6300 is close. I built a 416 very similar to that that made 540 with a dual plane and 950 carb, using a smaller solid roller cam. The torque peak will be higher than mine tho. I'd think 470-490tq @ 43-4400rpm would be what I'd expect.
The B wedge with it's shorter stroke and a CNC head in the 310 area will be undercarbed but not by much. But it will make it's power higher in the rpm band. I think the numbers would be similar, but slightly lower even at peak. I'd be looking for 510-525hp at 6800, with torque in the higher rpms too. I'd be looking for peak torque in the 5K area with a peak around 470 pound feet. To get things better, I'd run a higher static ratio, closer to 11.5 and a single plane intake for this one, plus a carb in the 950 area.
I have a program that uses a bunch of data points to approximate frictional losses for an engine... Interestingly, the hp it estimates being lost by the 4" is higher, but at 6600, the B wedge has the same hp loss as the 4" LA does at 6K.