Top Radiator hose angle on 340

Anyone know if it matters that the outlet height off the thermostat housing is higher then the port where it goes back into the radiator. Will this cause a air pocket issue ? I woulden't think so, but wondering how you guys are set up. I do have a overflow jug on the radiator with the hose running in the bottom, and I will be running a restrictor plate with a 3/4 " hole in it for a thermostat.