451 stroker, cut the crank or block?

Asked this question in the another thread and never got an answer, so I'm reposting. I have a 400 from my old Ramcharger and a forged 440 crank. This combo is going together for a stroker engine in my bro's '81 D150. I've heard compelling arguments on both sides of cutting the crank to fit the block or cutting the block to fit the crank.
Personally, I was thinking of cutting the block and going with crossbolt mains since it will have to be aligned anyway. The crank -and I'm still thinking on this one - may get knife edged for lightening it up and reducing windage. Stroker kits aren't gonna happen, not for the price, as the machining would still have to be done on the block and I already have the necessary components to assemble the bottom end, minus the mains.