Building a 410 stroker and need some advice

I would suggest that a flat top piston be used. (In a 360, it would be a 107.)
I forget what it would be for the stroker. But it will reduce the ratio to a pump gas level while retain enough compresion to run a heavy street cam.
Keep the piston in the block. The highest you want it would be at zero deck. Slightly below would be better since the extra stroke will induce more squeeze. (A high ratio.)

The cam your looking at is on the smallish side, being made smaller in a way due to the now bigger displacement of the engine size.

My questions are to do with the lifters, Hughes cam and transmission
Are the Rhoads lifters a good deal and how good are the Hughes cams?
What are your views on the Perfomance Automatic trannies?

I have used Rhodes lifters before and know a few people that have, but not those exact units your looking at. The variable lifter really isn't needed with your combo at all. The extra stroke of the engine is going to make mad crazy torqe along with the smallish cam.

(Strokers/big cube engines use more cam than a smaller engine. OR they eat up cam duration so you need to use a larger cam for the same performance target.)

Huges has there cams ground by someone. I forget who. There cams have agressive lift rates and high lifts in an attempt to maximize the valve train movement for the best possible air and fuel charge into the engine without going to a race style cam, which is more aggresive in it's valve action.

Like everyone else out there, huges gets cheers and jeers. There very much like every other aftermarket manufacturer in theres very happy people with no issues and unhappy people with issues. No one is exempt from problems with the stuff.

I have never heard of " Perfomance Automatic trannies"