500 Hp Slant 6

.600 lift 308*dur, big valves, 13.5-14.1 compression, flying toilet throttle body injection 900cfm, lots of head work!!!!!!, 1 5/8 primary headers-2 1/2 exhaust, custom pistons hung on 198 length h beams, lighten the crank some, oil mods or 2 and rev it about 7800rpm or so and have it live.

Then you'll need 5000 stall and 5 something gears
with the big slicks...

Or
Turbo it to death and get a manual 5-6 speed overdrive hooked up with 4.57's out back, to keep it drivable.