Causes of detonation?

I'm thinking that you have not checked your distributors curve and have to run a lot of initial timing to get it to idle but that pushes your total timing way over what you really need. Tell us what your initial and timing total are.

Moper is right about oil causing problems too, whether it be from valve guides or ring wear.

BTW, did you use the recommended valve springs from Lunati for that cam? Were they checked when in installed for bind and proper installed height?