On higher RPM engines you need more than .045 at times.I had a .060 over 440 with a set of Arias domed pistons and 516 Heads that had .100 milled off of.I had to put a .124 gasket on to keep the valves from hitting with my .650 Flat Tappet cam with 290o Duration at .050.
Now on the HEMI's it is a complete different Geometry to do to keep the valves from Over-Lap collision.
I have had a 501 C.I. motor with 62CC INDY Cyl Heads with a .692 Roller with 286o Duration at .050 and had the piston .020 out of the hole and a .042 gasket leaving .022 piston to head and .030 piston to valve clearance.I broke a rod in this motor and later come to the conclusion that the $800/set rod broke because of hitting the valve(impressions of valve on the pistons)on the piston.