Holley carb issue?

this is a brand new out of the box holley 600 dbl pumper mechanical secondaries manual choke carb.
the vacuum line under front bowl came plugged and i left it that way.
Not sure what screw you mean but i went over the whole carb and made sure everything was snug.

If you snugged the idle mixture screws it won't run.

photo_holley_idle_mix_screw.jpg