Supercharger or Not? Your Educated Opinion

That would depend on what my goal was. Fully ported eddy heads on that stroker engine will be good, especially with a roller cam.
Those blowers run out of steam quickly on 400cid engines!

Brain, we need to talk near future. This is one of the motors (actually individual parts) I wanted to bring down to you. As of right now, 408/W2s/6-71. Still waiting to see if you hear anything out of the Indy camp re: a new dedicated W2 blower manifold.