6.300 rods in a 416 stroker

First thing to do is figure out if those are Mopar rods or Chevy rods. I just finished up a 427 inch small block using 6.200 long Chevy SB rods. That combination worked just fine and it had a longer 4.125 inch stroke in it. So the 6.300 rods will work on a 4.00 inch stroke in terms of length. The problem might be the size of the big end, especially if it is a Mopar rod and not a Chevy rod. The Chevy rods are smaller and take up less space around the crankcase and oil pump area.

What's the compression height of the piston end up being with something like that? How does that affect the longevity?

I've really been interested in these "big cube" smallblocks, but I hear very mixed information on them lasting only a short while, while others tell me they drive them on the street for a long time with decent results.

The longer stroke really makes a motor with a lot of snort down low and it comes in right away which is why I like the idea.