First, we need to find out exactly what you're talking about here. "Intake center line" and "Lobe separation angle" are two completely different things. Intake center line refers to the method by which a camshaft is degreed.
Say you have a cam with a 112 lobe separation angle. Usually they are installed 4* advanced which means the intake centerline would be at 108*, meaning the cam still has the lobe separation angle of 112*, it is just INSTALLED 4* advanced at 108* intake center line.
The lobe separation angle is ground into the cam and cannot be changed. The intake centerline refers to where the cam is installed in the engine. So we need to know which you are talking about.