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To put the the V8 in there, you'll need adapting motor mounts/or a V8 K-frame. You'll need a form of V8 exhaust (be it manifolds or headers). The slant six electrical wiring will work (distributor, oil pressure gage, alt wires, etc) but the lengths may not be exact. The /6 throttle cable will also work, but you'll deal with the length (not a big deal). IF power steering, you'll need PS brackets for the V8 (your engine may come with them). Obviously, a V8 distributor (the engine may come with one). Pretty easy swap to be honest.
I've not done the manual transmission swap from /6 to V8, so others can help you there.