The biggest thing is to figure out what water pump you are going to run. CI pumps are on the drivers side (inlet), and the later alum. pumps are the passenger side. The timing cover marks are either cast into the drivers side, or a bolt on pointer can be used (as stock) from the 273. Make sure you use the correct balancer (diff. pos. timing marks). Be aware the intake bypass hose is smaller on the CI waterpump too, so if using an aftermarket intake, you'll have to bush down the intake side, or bush up the pump side. Also; the pulley set will be different between the alum and steel pump. old 273 alt. brackets are hard to find.
Once you know the pump, balancer, timing cover config., then go rad. shopping. If using an automatic radiator, just plug the cooler ports. Manual rads are harder to find. there are more radiator choices with a rad outlet on the pass. side.
On early A's; when putting in a 318 into a 273 car, I use all the 273 stuff I can. I'd get the stock radiator recored. If putting a SB into a S6 car, I prefer loading up with the later alum. pump stuff. Why? easier to find pulleys, cheaper waterpump, easier to line up the eddy intake with the alum. pump. Rad iwll be an aftermarket on for a later A body. I modify the opening in the rad support as needed.
First pict is a 318 in a 64 Valiant, alum. waterpump, later Abody stock rad, The second pict is the underside, showing the rad. outlet (pass. side)
The third pict is a 318 prepped to replace a 273 in a 65 early A. The alum. timing cover was used, so the 273 timing mark metal tabbed was used.